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2. Let your physician or nurse know when you have any problems along with your eyes.
   It may help to alter a couple of things about when and the
   place you sleep. Strive to go to mattress and
   get up on the identical time each day and spend a while enjoyable before
   you go to mattress. If you do come into contact with someone who has them, tell your healthcare team right
   away.
   Prednisone might increase blood glucose concentrations in individuals with diabetes and dosage changes of antidiabetic
   brokers (eg, insulin, glyburide) may be required.
   Administration with fluoroquinolone antibiotics (such as ciprofloxacin or levofloxacin) may enhance the chance
   of tendon rupture with fluoroquinolones. I
   acknowledge the contributions of many researchers within my department, which have contributed
   to the novel mechanisms of corticosteroids discussed
   on this review, and notably these of Dr Kazuhiro Ito and Professor Ian Adcock.
   I additionally acknowledge generous funding from the Wellcome Belief,
   Medical Research Council (U.K.), Asthma U.K., British Lung Basis, GlaxoSmithKline,
   AstraZeneca and Mitsubishi Pharma. New and more practical antioxidants are in development
   (Cuzzocrea et al., 2004) and selective iNOS inhibitors are already in clinical trials (Hansel et al., 2003).
   Prednisone could improve your danger of harmful effects from a reside vaccine.
   Stay vaccines include measles, mumps, rubella (MMR), rotavirus, yellow fever, varicella (chickenpox), one
   type of the typhoid vaccine and nasal flu (influenza) vaccine.

   Mineralocorticoids are important for sustaining homeostasis, significantly in situations
   the place blood stress regulation is compromised. Issues such as Addison’s
   disease, characterised by insufficient manufacturing
   of mineralocorticoids, require therapeutic administration of those steroids to revive stability.
   In other persistent inflammatory diseases, such as rheumatic arthritis and
   inflammatory bowel disease, there’s a excessive diploma of oxidative stress that will lead to impaired HDAC exercise and
   reduced corticosteroid responsiveness.
   Corticosteroids, usually just called steroids, are
   a type of anti-inflammatory medication that may deal
   with many various health circumstances. Since their discovery, steroids have infiltrated nearly every department of medicine
   and may be administered in practically each route available.
   The results of steroid use can vary widely, and the total spectrum of unwanted effects can be
   present even in patients taking low doses.
   A healthcare supplier will run tests to ensure they perceive your situation appropriately before prescribing prednisone.
   Prednisone is a drugs used to calm this confusion within the immune system.
   Assume of it as a peacekeeper that tells the body’s security staff to loosen up
   and cease attacking its personal cells. Prednisone
   isn’high t side effects (http://newslabx.csie.ntu.edu.tw) selective in its strategy; it targets varied autoimmune disorders
   from rheumatoid arthritis to lupus. Its broad application makes it a
   staple in drugs cupboards but additionally warrants a dialogue
   on its proper use and potential unwanted effects.

   Steroid hormones cause modifications within a cell
   by first passing through the cell membrane of the goal cell.

   However, take it straightforward and progressively increase your
   exercise level. Your doctor could give you a neighborhood anesthetic
   before your steroid injection to prevent pain. You might expertise a short lived improve in irritation after your injection, which may be
   painful. This should go away inside 24 hours as the steroid begins
   to work.
   Glucocorticoids additionally lower facilitated uptake of glucose in peripheral tissues
   to offer extra glucose for glycogen formation in the liver.
   This impact is particularly prevalent in leukocytes
   and could also be a serious contributing factor
   to the rapid elevation in blood glucose after steroid administration. The advanced mechanisms for the peripheral effects of
   glucocorticoids are nonetheless unclear, but persistent administration may find yourself in the atrophy of
   lymphatic tissue and muscle, osteoporosis, and thinning of the skin. Theophylline is the
   first drug that has been shown to activate HDAC, leading to
   marked potentiation of the anti-inflammatory results of corticosteroids (Ito et al.,
   2002b; Cosio et al., 2004b). This motion of
   theophylline isn’t mediated through phosphodiesterase inhibition or adenosine receptor antagonism
   and therefore appears to be a novel action of the drug (Ito et al., 2002b).
   In COPD macrophages low concentrations of theophylline are capable of restore HDAC exercise to
   regular and reverse steroid resistance of thee cells in vitro (Cosio et al., 2004b).

   In contrast, cross-sectional research demonstrated impaired CEC in AAS customers compared with age-matched, strength-trained nonusers and sedentary controls (139).
   It is possible that the upper dosages used, use of varied AAS, or completely different strategies used to measure CEC (which isn’t
   standardized), would possibly underlie these variations. In explicit, an affiliation between testosterone
   remedy and prostate cancer was shortly drawn based on animal experiments and limited case studies (81).
   Notably, the ventral prostate of the rat became the mannequin organ for androgenic
   activity within the renowned Hershberger androgen bioassay, which was developed in 1953 (82).

3. The major notable unwanted facet effects are likely to be testosterone suppression and
   ldl cholesterol alterations. Due to its less
   harsh nature, our sufferers have described Anavar as
   one of the “best steroids to get ripped” primarily based on its features vs.
   unwanted effects profile. Each of these steroids are fast-acting, causing visual modifications to body composition, particularly in regard to body fats, within the first few days of supplementation. Its potent
   androgenic properties stimulate fat loss when cutting while reducing water levels
   due to it antagonizing the aromatase enzyme.
   It prompts pathways like PI3K/Akt/mTOR17, that are essential for growing muscle measurement
   and energy. BPC-157 can improve the expression of progress hormone receptors in tendon cells15.
   This signifies that it may possibly improve the results of
   progress hormone, which is crucial for muscle growth and repair.
   CJC-1295 is an artificial progress hormone-releasing hormone (GHRH) analog that
   has several benefits for bodybuilding. When we carry weights
   or train intensely, our muscle fibers develop microscopic tears – a standard a part of getting stronger.

   Put merely, the use of HCG following one of the above strategies ensures you start recovering your testosterone production as quickly as you begin your PCT.
   Joint and bone help can be why some individuals add Deca to a long cycle as a secondary compound.
   Adverse libido impacts are potential; dosage is usually set at half of the testosterone dose to combat this.
   Equipoise has the added advantages of boosting the urge for food and improving stamina, vascularity,
   and pumps. EQ can enhance blood stress, so dosing is usually
   set at 50-75% of the testosterone dose to reduce back the cardiovascular
   risk.
   Additionally, testosterone has a optimistic effect on bone
   density, which is especially important for athletes partaking in high-impact activities.
   Understanding natural steroids for bodybuilding provides people with safer options to realize their health
   goals whereas minimizing potential well being risks.
   These compounds offer an alternative approach to constructing muscle naturally by stimulating protein synthesis
   and optimizing hormone ranges. However, it’s at all
   times beneficial to seek the guidance of professionals earlier than incorporating any
   new supplements into your routine.
   With Winsol, you’ll see a visual difference in your body’s veins and arteries,
   making your muscle tissue look more outlined and toned.
   Anabolic-androgenic steroids (AAS) are lab-made testosterone dietary supplements.
   They’re by no means a good choice for constructing muscles or strength due to
   their numerous negative unwanted effects. Nonetheless, some athletes and bodybuilders illegally use these legal steroids dbol (mitsfs-wiki.mit.edu) to boost muscle mass or efficiency.
   For the most effective results, match the Masteron dose to your well being and fitness targets.

   For bounce-back after the cycle, a plan usually consists of 50mg of specific meds every day for two weeks.
   To improve the results of Primobolan, many users choose to
   stack it with different compounds.
   However when you, having low testosterone, start taking
   steroids for a bulking or slicing cycle, it might possibly cause
   vital harm. This is as a result of medical and sports activities doses are significantly completely different.

   Sports Activities doses are all the time greater,
   and they simply block the work of your sex glands.

   As A Outcome Of of its energy, some athletes may look past possible unwanted effects and give it
   a go. Winstrol is secure when taken correctly- as
   an injectable, however will otherwise pressure your liver.
   It has been positioned on this list because it is considered safe for girls.
   Withdrawal signs similar to temper swings, fatigue, or melancholy can happen when someone tries to stop taking steroids.
   Signs of coronary heart issues can include chest ache, breathlessness, and weird tiredness.

   A Primobolan-only cycle will produce related results to an Anavar-only cycle.
   Some ladies might increase their dosage to above seventy five mg per day; nevertheless, we find that going past this increases
   the risk of virilization. In research, Proviron has been shown to
   suppress whole testosterone levels in megadoses of 450 mg/day (5).
   Nonetheless, in normal bodybuilding doses, testosterone suppression from Proviron is extra acute compared to different steroidal compounds.
   Other than Winstrol being an oral steroid and never being as anabolic as trenbolone, the principle other difference is that
   Winstrol doesn’t fill out the muscles as a lot.
   We discover that users on Winstrol can sometimes look somewhat
   flat (despite building muscle), which is due to intracellular
   water depletion.
   Breakthroughs have resulted in detecting particular steroid metabolites for twice as lengthy as beforehand attainable.
   This signifies that only remaining traces of metabolites could slip previous the drug testing
   techniques; these traces can now be picked up to return a positive outcome.
   Long-term metabolites combined with long-term storage of samples additionally contribute to retrospective
   drug testing functionality.

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8. Thus, these drugs are often used illegitimately to gain a aggressive edge in sports activities.
   Approximately 2% of females and 6% of males worldwide use or abuse anabolic steroids, with related estimates for
   the Usa. Steroid use in feminine bodybuilders is a topic that always sparks
   debate.
   With responsible use, Oxandrolone can be a priceless software in a female bodybuilder’s arsenal.

   The key lies in finding the best balance that caters to your bodybuilding objectives without compromising
   your general well being. Bear In Mind, no quantity of enhanced muscle definition or power is worth jeopardizing your well-being.
   The path to a sculpted physique is a marathon,
   not a sprint—patience, consistency, and safety are your
   greatest allies on this journey.
   Deca Durabolin is a bulking steroid additionally capable
   of including notable quantities of muscle mass by enhancing
   protein synthesis and nitrogen retention in muscle fibers.
   Deca Durabolin additionally increases muscle fullness by rising intracellular fluid quantity.

   Nevertheless, it’s equally effective by way of its capacity
   to build muscle tissue. One notable distinction is that customers regularly keep muscle measurement
   once they discontinue trenbolone, whereas they usually lose intracellular water after they discontinue Dianabol or Anadrol.
   We find that endogenous testosterone ranges
   sometimes normalize a number of weeks following cycle cessation.
   This article explains the advantages and the potential risks of anabolic steroid use.
   Common blood exams and check-ups help catch problems with hormones,
   cholesterol, or liver perform. Keep Away From SARMs if you’re pregnant, breastfeeding, or making an attempt to get pregnant—just not definitely
   value the risk.
   At the time, the sport was gaining more reputation and visibility, and it was
   during this period that ladies began to have their own divisions in major bodybuilding competitions.
   Anavar, with its mild properties, was seen as a super possibility for women who were looking to achieve muscle mass without experiencing androgenic side
   effects. Sure, Winstrol is taken into account more appropriate for girls compared to
   many different steroids because it generally causes
   fewer masculinizing results.
   Long-cycle testosterone dosage will range from 200mg/weekly on the low
   end if you’re looking for HRT only… Up to 800mg or
   even more at the high finish when cruising on an extended cycle.
   If you’re blasting, you’ll take a glance at even higher doses,
   however I’ll cover that in the short cycle section below.

   With this frontloading technique comes each faster results and a extra
   rapid onset of unwanted effects firstly of the cycle.
   Suppose you’re particularly delicate to androgenic and different unwanted aspect effects.

   In that case, frontloading won’t be for you, nevertheless it does provide an extra option for individuals who favor to not
   undertake a kickstart using an oral steroid. Frontloading Testosterone Enanthate
   can get your blood plasma ranges as much as 500mg a lot quicker.

   Nevertheless, the misuse of Clenbuterol can lead to critical health issues.
   There have been situations the place excessive doses have
   brought on hospitalizations, including a case the place a man skilled
   a heart price of 254 beats per minute following a substantial overdose.
   Apparently, Clenbuterol has shown some anabolic traits, notably
   in its capability to grow skeletal muscle in animal studies.

   As the first male natural steroid hormone, unmodified
   testosterone steroids (synthetic forms of the hormone) are normally the first place we begin if using steroids for the primary time.
   Sometimes, when you use Testosterone Enanthate at 500mg weekly (a
   standard dosage), it can take nicely over one month in your blood ranges to succeed
   in the purpose of 500mg of the steroid. Growing the dose
   just isn’t at all times the best option as a end result of you’ll have extra unwanted side effects.

   Conversely, Anavar is predominantly utilized for its potent fat-burning properties and
   skill to expel water, rising vascularity and muscle tone.
   During testosterone supplementation, the pituitary gland signals the testes to stop
   producing testosterone, contributing to hypogonadism (3).

   This process occurs as a end result of supraphysiological levels of serum testosterone and the physique
   attempting to take care of homeostasis. The U.S.
   Food and Drug Administration (FDA) has permitted these
   medication for use in pubertal-age boys and males with circumstances that trigger
   a testosterone deficiency. Let’s get into what steroids are, What Is A Dangerous Effect Of Anabolic Steroids; Koreatesol.Org, they’re used for (both legally and illegally),
   and how to discover some secure options to steroids that’ll give you the similar
   outcomes. The growth rate of those adjustments will rely upon the
   steroids being used, their severity and dosage.

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13. It has additionally been prescribed to osteoporosis sufferers, helping
    to cut back pain by increasing bone density via the stimulation of bone formation. Anabolic steroids
    have the ability to compromise traits relating to a person’s
    gender. If you might be utilizing winstrol benefits, at all times comply with the directions offered by your doctor.
    If you feel you need further info relating to dosage, seek the guidance of your doctor.
    By No Means buy Winstrol from anyone offering
    low cost prices or inferior merchandise.
    If you’re using birth control tablets, then you want to maintain your physician informed about your cycle
    and what sort of capsule you are taking.
    The core perform of steroids is to lower irritation and suppress the
    immune system. This can be notably beneficial in bodybuilding, an activity that usually causes significant pressure and inflammation within the muscles as a result of rigorous training.
    Winstrol, scientifically often identified as Stanozolol,
    is broadly revered locally of energy sports – for good cause.
    This anabolic steroid is a go-to for a lot of sportsmen and bodybuilders who need to improve their athletic skills and
    physique because of its exceptional qualities.
    This powerful anabolic ‌steroid is coveted for its capability to
    enhance‌ muscle energy and definition⁤ whereas aiding in fat loss.
    ⁤With cautious administration ⁤and responsible dosage, Winstrol empowers girls to
    reach new heights in ⁢their bodily performance.

    Earlier Than ⁤answering this query, it’s ⁣crucial to address the potential risks
    and concerns involved. Ladies must be aware that Winstrol⁤ is classified as a veterinary drug and
    has not been⁢ approved by the FDA ‍for human use.
    As such,​ its safety and effectiveness in⁤ feminine
    users aren’t totally understood‌ or⁤ supported by scientific
    research. Additionally, reach out to a healthcare professional when you experience
    any allergic reactions after starting Win-Max. Win-Max is a legal and safe choice for enhancing your health
    journey, so you must use it confidently!
    Win-Max is a legal and more secure various to Winstrol,
    specially made for cutting functions and weight reduction while
    making certain muscle achieve. We have discovered that Nolvadex or Clomid is enough for single-steroid cycles; nonetheless, all three drugs may be utilized
    collectively if a potent stack has been taken. HCG is predominantly
    used for its capability to restore sperm production quite than to
    recover endogenous testosterone by itself. This is generally a
    short-term aspect impact; nevertheless, as a end result of efficiency of Winstrol, low
    testosterone ranges can be skilled for a number of weeks or
    months following cycle cessation. With Winstrol depleting
    intracellular water ranges, we find it isn’t essentially the most potent of AAS at enhancing strength.
    This is due to decreased levels of adenosine triphosphate production contained in the muscle cells, a protein molecule crucial for vitality.

    Initiating with smaller doses permits you to observe how your body
    reacts and provides you the possibility to step up progressively
    whenever you really feel snug. Apart from serving to you
    get higher sleep, magnesium has been shown to assist with constipation, weight reduction,
    and taking a every day supplement might even cut back your danger of
    dementia. Winstrol injections are actually a quantity of occasions more practical than oral ingestion. Nonetheless, oral tablets sometimes have the benefit over injections as they are more likely to harmonize with different steroids.

    Nevertheless, clenbuterol is bought underneath the counter, where dietary supplements are often tainted (10); thus, it is difficult to know
    if users are receiving genuine clenbuterol. However, if a person begins to overeat
    following a clenbuterol cycle and stops coaching, then fats
    accumulation can occur. Albuterol additionally burns fat via the process
    of thermogenesis by way of the stimulation of the CNS.

    Nitric-Max is an awesome bodybuilding complement formulated to help towards blood move & oxygen circulation,
    growing your power, vitality & restoration. The use of this steroid can give rise to speedy
    recovery occasions as a result of its anti-inflammatory traits.
    Lowered recovery occasions mean athletes can ramp up training intensity and frequency,
    leading to improved efficiency over time. For ladies navigating training plateaus, high-volume
    workloads, or defined physique objectives, this complement presents a serious alternative to legacy
    options rooted in artificial compounds.
    And if quicker recovery times have been notable
    through the solo cycle, they might be much more outstanding
    in a stacked cycle, given the synergistic functioning of coupled compounds.

    In conclusion, when female bodybuilders are starting their journey with
    Winstrol, they should prioritize safety by taking a lower dose and gauging their
    body’s response. Correct consideration to dosage and a willingness to
    make adjustments based on private experiences
    can in the end lead to much more effective, secure, and passable outcomes.
    However, like another steroid, Winstrol doesn’t come without the potential of getting undesired results.
    It’s crucial for ladies to garner enough knowledge concerning the product
    and consider individual well being status to make sure its benefits outweigh
    the potential drawbacks. And whereas Stanozolol presents quite a few benefits, maintaining a tally of food plan, following a rigorous training schedule, and taking sufficient rest
    are non-negotiable aspects to maximise results. During a chopping cycle, most feminine bodybuilders and fitness fashions start to
    chop back on energy.
    Moreover, testosterone just isn’t significantly hepatotoxic,
    as it’s an injectable steroid. Hepatic and cardiac well being are
    the 2 major considerations we have when someone is utilizing anabolic steroids.
    Beyond 6 weeks, the hepatotoxicity and suppression risks improve sharply — particularly should you’re not
    working correct PCT or assist supplements.

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15. This is doubtlessly as a outcome of decrease volume
    administered with each injection and reduced resulting estrogen conversion in comparability with Testosterone Cypionate.
    While they’re precisely the same steroid once
    the ester detaches, person experience is often a little different between these two testosterone esters when it comes
    to side effects. All Through the cycle, use zero.5mg/ed Arimidex to fight
    estrogen-related side effects (gynecomastia).
    So if these unwanted virilizing unwanted side effects start to seem and you want them gone, stop
    using the steroid, and the signs will recede within days.
    Testosterone Propionate is a steroid that few ladies will select
    to use due to the intense virilizing effects that testosterone will trigger in girls, even at very low doses.

    Use your regular food plan as a base to gauge your usual every day intake of proteins, carbs,
    and fats, after which figure out exactly what you’ll must add
    or enhance to satisfy your objectives when on a
    cycle. Too typically, we think we’re getting sufficient calories,
    but we’re not, and any deficiency will kill your outcomes when on gear.
    Since every muscle or muscle group recovers faster after being worked on, you’ll find a way to goal each
    muscle far more actually because those restoration instances are significantly shortened.
    That doesn’t mean overtraining or forgetting about all-important rest and
    sleep, however you’ll be able to fit up to twice as many workouts concentrating on a muscle group
    into the identical interval. If you took a 5-day break after working one a
    part of the physique, you would see this drop-down to just two or three days.
    When on a cycle with virtually any compound, you’ll notice that your restoration will substantially enhance.

    If you prefer D-bol over testosterone, you have to slowly
    improve the dose over a interval of four weeks to realize the
    desired outcomes. Don’t be too harsh on yourself because it’d invite a
    lot of unwanted side effects that would be exhausting to get rid of.
    Ever since, Arnold has been very open about saying that his PED regimen is made up of two
    medicine, testosterone and D-bol. He opened up about a fact in an interview where he put ahead that bodybuilding had at all times
    been a protected sport, however now individuals are dying due to the overdoses.
    It peaks in an hour, so some take it once a day or divide a dosage throughout the
    day to keep up its level within the blood. He and Seba Pharmacies collectively perfected
    this medicine to convey it to the market as an anabolic
    steroid with greater anabolic properties and lesser androgenic unwanted
    facet effects.
    In the US, Testosterone Propionate has been discontinued for pharmaceutical manufacturing.
    You won’t discover any US-manufactured products obtainable,
    although this steroid is still technically permitted to be used by the FDA.
    The only method to get pharmaceutical grade Testosterone Propionate in the
    US in the meanwhile is through a compounding pharmacy if you’re able to find one.
    Getting pharmaceutical-grade Testosterone Propionate means getting the very best high quality and most pure type
    obtainable. The benefits of Testosterone Propionate are engaging,
    however we can’t look at the positives without additionally contemplating the negatives.

    With correct post-cycle remedy and frequent blood testing,
    it goes to be able to management side effects and is
    a quality method of beginning steroids. [newline]It’s crucial to remember of these risks prior to
    starting any anabolic steroid cycle. Selecting one of the best beginner
    steroids is essential to those who are organizing their first cycle.
    Among one of the best steroids for novices, that are favored
    for their performance and relatively decrease aspect effect profile,
    the following are enumerated below. Steroids improve nitrogen retention and enhance testosterone levels, which straight away
    boosts strength and energy output in compound
    workout routines. Injectable steroids similar to testosterone enanthate provide
    clean ranges of hormone and are liver-damaging
    much less. A properly planned first steroid cycle will often contain testosterone enanthate,
    presumably stacked with dianabol and test cycle or Anavar.

    Halotestin must be run for no longer than three weeks, with 30mg day by day beneficial as the utmost.
    Take Tren at 300mg weekly, Anavar at 50mg every day, and don’t overlook your
    testosterone prop at 300mg weekly. It is perfect for contest prep, particularly when you add Halotestin for
    the final three weeks of the cycle, which can harden up the physique while boosting energy fairly dramatically.
    This might be the best stack ever for chopping – it actually was for me!

    Nevertheless, trenbolone doesn’t induce aromatization, causing significant elevations in blood pressure,
    which are attributed to vast reductions in HDL. Since trenbolone is an injectable steroid, it does
    not compromise the liver like testosterone.
    Androgenic side effects are common with Anadrol, regardless of
    its low androgenic rating of 45. Consequently, male sample
    baldness, seborrhea, acne vulgaris, and benign prostatic hyperplasia (BPH) have been famous
    in analysis (4). Anavar is a C-17 alpha-alkylated oral steroid; thus, it is processed by the liver
    upon absorption into the bloodstream. Throughout testosterone administration, researchers
    report that the pituitary gland alerts the testes to cease
    producing pure testosterone, contributing to hypogonadism
    (3).
    Primobolan is most dear when utilized in a slicing cycle with enhanced nitrogen retention, serving to to retain muscle and the potential
    for wonderful fat loss via lipolysis. One of the several medical conditions this steroid was used to deal with was AIDS as a end
    result of Primobolan positive impact on the immune system,
    making this a novel trait of this steroid. A Tren cycle
    has been shown to have fat-burning and anti-catabolic results, so it helps retain muscle.
    It’s tremendous for chopping and common physique recomposition however comes with downsides, together with
    being highly suppressive and known as a libido killer. It
    can bring about drastic temper modifications and insomnia, as properly as
    androgenic results like zits and hair loss. Subsequently, most customers like to use
    Tren for restricted intervals to reduce back the severity of
    side effects.
    Most steroid customers are conversant in the legendary compound Dianabol, which EQ shares a virtually equivalent chemical structure with.
    Still, a slight modification permits each one to have a
    different impact on the physique. This makes it attainable to make use
    of these very similar but utterly different-acting steroids together in a
    cycle with great benefit. Recognized to provide glorious bulking results, Sustanon was one
    other popular single cycle found 10 years ago. This cycle usually lasts 8-12 weeks, hanging a stability between permitting enough time for noticeable gains while minimizing attainable side effects.
    Testosterone Enanthate and Nandrolone Decanoate Cycle The Testosterone Enanthate and Nandrolone
    Decanoate cycle lasts for 17 weeks. For the primary 10 weeks you’re
    taking 500mg of testosterone enanthate weekly mixed with 400mg of Nandrolone Decanoate weekly.

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